A&Ox2 | Anil Makam | Substack

A&Ox2

Reorienting the conversation in medicine and health care

Launched 4 months ago

Metformin for Prediabetes: Treating the Label, Not the Patient

Prediabetes is useful as a risk marker. It is a signal to take metabolic health seriously. But metformin for prediabetes is a different claim. It says…

May 20•Anil Makam


Latest Top Discussions


Tales from the Wards 1.0

A potpourri of clinical pearls from my practice

Apr 22•Anil Makam


Flawed Research is Not Hypothesis Generating

An Example of Thickened Fluids in Dementia

Apr 8•Anil Makam


'Learners' or 'Doctors'?

Rethinking language and responsibility in medical training

Mar 26•Oanh Kieu Nguyen


Hyponatremia: Does Correcting it Help?

Hyponatremia reliably predicts bad outcomes. But does correcting it fix them? A new randomized trial makes that uncomfortable truth harder to ignore.

Mar 24•Anil Makam


If Jesus Practiced Medicine Today, He'd Only Generate 68.27 wRVUs

A satirical commentary on valuing what is easiest to measure, not what matters most

Mar 19•Anil Makam


Resmetirom: a new drug that is already outclassed

Why doctors should abandon the new shiny drug for MASH in favor of a far superior drug class.

Mar 17•Anil Makam


Conferencing is Better in the Public Square

If the goal in academia is exchange, networking, and collaborations, then we should stop pretending the hotel ballroom is the only or even the best way…

Mar 12•Anil Makam